AGER antibody
Volume: 100 µg
Purification: protein A+G purified
Form: liquid
Purity: 95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 1B6
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background: Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Immunogen: advanced glycosylation end product-specific receptor
Synonyms: AGER, RAGE
Observed MW: 43 kDa
Uniprot ID: Q15109
Reactivity: Human, Rat
Tested Application: ELISA, WB
Recommended dilution: WB: 1: 1000-1: 5000
Gene ID: 177
Research Area: Immunology, Signal Transduction, Developmental biology
Internal Reference:
FNab09951