ALCAM antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts(PubMed: 7760007, PubMed: 15496415, PubMed: 15048703, PubMed: 16352806, PubMed: 23169771, PubMed: 24945728). Promotes T-cell activation and proliferation via its interactions with CD6(PubMed: 15048703, PubMed: 16352806, PubMed: 24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6(PubMed: 15294938, PubMed: 16352806). Mediates homotypic interactions with cells that express ALCAM(PubMed: 15496415, PubMed: 16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow(PubMed: 24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction(PubMed: 23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions(PubMed: 15496415, PubMed: 23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation(By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons(By similarity). Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. Immunogen: activated leukocyte cell adhesion molecule Synonyms: ALCAM, CD166, CD166 antigen, FLJ38514, MEMD Observed MW: 110 kDa Uniprot ID: Q13740 Reactivity: Human Tested Application: ELISA, IHC, WB Recommended dilution: WB: 1: 200-1: 2000; IHC: 1: 20-1: 200 Gene ID: 214 Research Area: Stem Cells, Immunology, Signal Transduction, Developmental biology