AIM2 antibody
Volume: 100 µg
Purification: Immunogen affinity purified
Form: liquid
Purity: 95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID:
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Immunogen: absent in melanoma 2
Synonyms: Absent in melanoma 2, AIM2, PYHIN4
Observed MW: 40 kDa
Uniprot ID: O14862
Reactivity: Human
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1: 500-1: 5000; IHC: 1: 20-200
Gene ID: 9447
Research Area: Metabolism
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