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AHR antibody

https://www.academycancerimmunology.org/web/image/product.template/2987/image_1920?unique=b611535
Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes(such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. Immunogen: aryl hydrocarbon receptor Synonyms: Ah receptor, AHR, aryl hydrocarbon receptor, bHLHe76 Observed MW: 105 kDa Uniprot ID: P35869 Reactivity: Human, Mouse Tested Application: ELISA, WB, IHC, IP Recommended dilution: WB: 1: 200-1: 2000; IP: 1: 200-1: 2000; IHC: 1: 20-1: 200 Gene ID: 196 Research Area: Epigenetics, Signal Transduction, Metabolism

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Internal Reference: FNab00231