ADCY6 antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors(PubMed: 17916776, PubMed: 17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells(PubMed: 17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion(By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function(By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol(PubMed: 17916776). Contributes to bone cell responses to mechanical stimuli(By similarity). Immunogen: adenylate cyclase 6 Synonyms: AC6, ADCY6, adenylate cyclase 6, Adenylate cyclase type 6, Adenylate cyclase type VI, Adenylyl cyclase 6, ATP pyrophosphate lyase 6, DKFZp779F075, KIAA0422 Observed MW: 131 kDa Uniprot ID: O43306 Reactivity: Human, Mouse, Rat Tested Application: ELISA, WB, IP Recommended dilution: WB: 1: 200-1: 2000; IP: 1: 200-1: 1000 Gene ID: 112 Research Area: Signal Transduction, Metabolism