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ADAM17 Antibody

https://www.academycancerimmunology.org/web/image/product.template/1979/image_1920?unique=b611535
Size : 50 µL Clone Number: 5A1 Aliases: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b), ADAM17, CSVP TACE Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P78536 Immunogen: A synthesized peptide derived from human ADAM17 Host: Reactivity: Human Tested Applications: ELISA, IF; Recommended dilution: IF: 1: 20-1: 200 Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ADAM17 Research Areas: Neuroscience; Cancer; Cell biology; Metabolism; Signal transduction; Stem cells

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Internal Reference: CSB-RA797631A0HU