ADAM17 Antibody
Size : 50 µL
Clone Number: 5A1
Aliases: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b), ADAM17, CSVP TACE
Product Type: Recombinant Antibody
Immunogen Species: Homo sapiens (Human)
UniProt ID: P78536
Immunogen: A synthesized peptide derived from human ADAM17
Host:
Reactivity: Human
Tested Applications: ELISA, IF; Recommended dilution: IF: 1: 20-1: 200
Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Clonality: Monoclonal
Isotype: Rabbit IgG
Purification Method: Affinity-chromatography
Conjugate: Non-conjugated
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: Liquid
Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names: ADAM17
Research Areas: Neuroscience; Cancer; Cell biology; Metabolism; Signal transduction; Stem cells
Internal Reference:
CSB-RA797631A0HU