ACO1 Antibody

Size : 50 µL Clone Number: 22C10 Aliases: Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1), ACO1, IREB1 Product Type: Recombinant Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P21399 Immunogen: A synthesized peptide derived from human ACO1 Host: Reactivity: Human Tested Applications: ELISA, WB, IF, FC; Recommended dilution: WB: 1: 500-1: 2000, IF: 1: 50-1: 200, FC: 1: 50-1: 200 Background: Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004). {ECO: 0000269|PubMed: 1281544, ECO: 0000269|PubMed: 1946430, ECO: 0000269|PubMed: 23891004, ECO: 0000269|PubMed: 8041788}.; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO: 0000269|PubMed: 1281544, ECO: 0000269|PubMed: 1946430, ECO: 0000269|PubMed: 8041788}. Clonality: Monoclonal Isotype: Rabbit IgG Purification Method: Affinity-chromatography Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ACO1 Research Areas: Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism; Signal transduction