AKR1A1 Antibody

Size : 100 µL Clone Number: Aliases: AK1A1_HUMAN antibody; Akr1a1 antibody; Alcohol dehydrogenase [NADP+] antibody; Alcohol dehydrogenase antibody; Aldehyde reductase antibody; Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody; Aldo-keto reductase family 1 member A1 antibody; ALDR1 antibody; ALR antibody; ARM antibody; DD3 antibody; MGC12529 antibody; MGC1380 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P14550 Immunogen: Synthesized peptide derived from C-terminal of Human AKR1A1. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Bohren K.M., J. Biol. Chem. 264: 9547-9551(1989). Fujii J., Cytogenet. Cell Genet. 84: 230-232(1999). Barski O.A., Genomics 60: 188-198(1999). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AKR1A1 Research Areas: Cancer;Cell biology;Metabolism;Signal transduction