AIM2 Antibody

Size : 50 µL Clone Number: Aliases: Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_HUMAN antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O14862 Immunogen: Fusion protein of Human AIM2 Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 1000-1: 5000, IHC: 1: 50-1: 200 Background: Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN- , AIM2 is thought to act as a tumor suppressor by repressing NF B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AIM2 Research Areas: Epigenetics and Nuclear Signaling;Cancer