ALCAM Antibody

Size : 50 µL Clone Number: Aliases: Activated leukocyte cell adhesion molecule antibody; ALCAM antibody; ALCAM protein antibody; CD 166 antibody; CD166 antibody; CD166 antigen antibody; CD166_HUMAN antibody; FLJ3851 antibody; FLJ38514 antibody; MEMD antibody; MGC71733 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13740 Immunogen: Recombinant Human CD166 antigen protein (28-180AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed: 7760007, PubMed: 15496415, PubMed: 15048703, PubMed: 16352806, PubMed: 23169771, PubMed: 24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed: 15048703, PubMed: 16352806, PubMed: 24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed: 15294938, PubMed: 16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed: 15496415, PubMed: 16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed: 24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed: 23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed: 15496415, PubMed: 23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). Clonality: Polyclonal Isotype: IgG Purification Method: Antigen Affinity Purified Conjugate: Non-conjugated Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ALCAM Research Areas: Tags & Cell Markers; Immunology