ADD1 (Ab-726) Antibody

Size : 100 µL Clone Number: Aliases: ADD A antibody; ADD1 antibody; ADDA antibody; ADDA_HUMAN antibody; Adducin 1 (alpha) antibody; Alpha adducin antibody; Alpha-adducin antibody; Erythrocyte adducin alpha subunit antibody; Erythrocyte adducin subunit alpha antibody; MGC3339 antibody; MGC44427 antibody; OTTHUMP00000151163 antibody; OTTHUMP00000151164 antibody; OTTHUMP00000151165 antibody; OTTHUMP00000218664 antibody; OTTHUMP00000218665 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P35611 Immunogen: Peptide sequence around aa.724~728 (T-P-S-F-L) derived from Human ADD1. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB, IHC, IF; WB: 1: 500-1: 1000, IHC: 1: 50-1: 200, IF: 1: 100-1: 200 Background: Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102(35): 12407-12 Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332(2): 347-51 Barkalow KL, et al. J Cell Biol 2003 May 12; 161(3): 557-70 Clonality: Polyclonal Isotype: IgG Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjugate: Non-conjugated Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ADD1 Research Areas: Tags & Cell Markers;Signal transduction