CAMKK2 Antibody

Size : 100 µL Clone Number: Aliases: Calcium/calmodulin dependent protein kinase beta antibody; Calcium/calmodulin dependent protein kinase kinase 2 antibody; Calcium/calmodulin dependent protein kinase kinase 2 beta antibody; Calcium/calmodulin dependent protein kinase kinase beta antibody; Calcium/calmodulin-dependent protein kinase kinase 2 antibody; Calcium/calmodulin-dependent protein kinase kinase beta antibody; CaM kinase kinase beta antibody; CaM KK beta antibody; CaM-kinase kinase 2 antibody; CaM-kinase kinase beta antibody; CaM-KK 2 antibody; CaM-KK beta antibody; CaMKK 2 antibody; CAMKK antibody; CaMKK beta antibody; CAMKK beta protein antibody; Camkk2 antibody; CAMKKB antibody; KKCC2_HUMAN antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q96RR4 Immunogen: Synthesized peptide derived from internal of Human CAMKK2. Host: Rabbit Reactivity: Human Tested Applications: ELISA, WB, IHC; WB: 1: 500-1: 3000, IHC: 1: 50-1: 100 Background: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals By similarity. Seems to be involved in hippocampal activation of CREB1 By similarity. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. Hsu L.-S., J. Biol. Chem. 276: 31113-31123(2001). Anderson K.A., J. Biol. Chem. 273: 31880-31889(1998). Ishikawa Y., FEBS Lett. 550: 57-63(2003). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CAMKK2 Research Areas: Cancer;Signal transduction