ADD2 Antibody

Size : 50 µL Clone Number: Aliases: ADD 2 antibody; ADD2 antibody; ADDB antibody; ADDB_HUMAN antibody; Adducin 2 (beta) antibody; Adducin2 antibody; Beta adducin antibody; Beta-adducin antibody; Erythrocyte adducin subunit beta antibody; OTTHUMP00000203378 antibody; OTTHUMP00000203908 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P35612 Immunogen: Fusion protein of Human ADD2 Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC; ELISA: 1: 1000-1: 2000, IHC: 1: 15-1: 50 Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ADD2 Research Areas: Tags & Cell Markers;Signal transduction