AMFR Antibody, HRP conjugated

Size : 50 µg Clone Number: Aliases: AMF receptor antibody; AMF receptor isoform 1 antibody; AMF receptor isoform 2 antibody; AMFR antibody; AMFR2_HUMAN antibody; Autocrine motility factor receptor antibody; Autocrine motility factor receptor precursor; isoform 1 antibody; Autocrine motility factor receptor precursor; isoform 2 antibody; E3 ubiquitin-protein ligase AMFR antibody; gp78 antibody; isoform 2 antibody; RING finger protein 45 antibody; RNF 45 antibody; RNF45 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q9UKV5 Immunogen: Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: HRP Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AMFR Research Areas: Cancer; Cell biology