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AIRE Antibody

https://www.academycancerimmunology.org/web/image/product.template/3137/image_1920?unique=b611535
Size : 100 µL Clone Number: Aliases: AIRE antibody; AIRE_HUMAN antibody; AIRE1 antibody; APECED antibody; APECED protein antibody; APS1 antibody; APSI antibody; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody; Autoimmune regulator antibody; Autoimmune regulator protein antibody; PGA1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O43918 Immunogen: Synthesized peptide derived from internal of Human AIRE. Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IF; WB: 1: 500-1: 3000, IF: 1: 100-1: 500 Background: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. Nagamine K., Nat. Genet. 17: 393-398(1997). Aaltonen J., Nat. Genet. 17: 399-403(1997). Hattori M., Nature 405: 311-319(2000). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AIRE Research Areas: Epigenetics and Nuclear Signaling;Immunology

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Internal Reference: CSB-PA274868