AKAP10 Antibody

Size : 100 µL Clone Number: Aliases: AKAP10A-kinase anchor protein 10 antibody; mitochondrial antibody; AKAP-10 antibody; Dual specificity A kinase-anchoring protein 2 antibody; D-AKAP-2 antibody; Protein kinase A-anchoring protein 10 antibody; PRKA10 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: O43572 Immunogen: Synthesized peptide derived from Internal of Human AKAP10. Host: Rabbit Reactivity: Human, Mouse, Rat Tested Applications: ELISA, WB; WB: 1: 500-1: 3000 Background: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase By similarity. Wang L., Proc. Natl. Acad. Sci. U.S.A. 98: 3220-3225(2001). Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14: 2121-2127(2004). Clonality: Polyclonal Isotype: IgG Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjugate: Non-conjugated Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form: liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AKAP10 Research Areas: Signal transduction