AKAP10 Antibody
Size : 100 µL
Clone Number:
Aliases: AKAP10A-kinase anchor protein 10 antibody; mitochondrial antibody; AKAP-10 antibody; Dual specificity A kinase-anchoring protein 2 antibody; D-AKAP-2 antibody; Protein kinase A-anchoring protein 10 antibody; PRKA10 antibody
Product Type: Polyclonal Antibody
Immunogen Species: Homo sapiens (Human)
UniProt ID: O43572
Immunogen: Synthesized peptide derived from Internal of Human AKAP10.
Host: Rabbit
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB; WB: 1: 500-1: 3000
Background: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase By similarity.
Wang L., Proc. Natl. Acad. Sci. U.S.A. 98: 3220-3225(2001).
Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
The MGC Project Team, Genome Res. 14: 2121-2127(2004).
Clonality: Polyclonal
Isotype: IgG
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugate: Non-conjugated
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names: AKAP10
Research Areas: Signal transduction
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