A2M Antibody

Size : 50 µg Clone Number: Aliases: A2m antibody; A2MG_HUMAN antibody; Alpha 2 M antibody; Alpha 2M antibody; Alpha-2-M antibody; Alpha-2-macroglobulin antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody; CPAMD5 antibody; DKFZp779B086 antibody; FWP007 antibody; S863 7 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P01023 Immunogen: Recombinant Human Alpha-2-macroglobulin protein (1216-1467AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC: 1: 20-1: 200, IF: 1: 50-1: 200 Background: Is able to inhibit all four classes of proteinases by a unique \'trapping\' mechanism. This protein has a peptide stretch, called the \'bait region\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: A2M Research Areas: Cardiovascular; Cell biology