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AGER Antibody, Biotin conjugated

https://www.academycancerimmunology.org/web/image/product.template/2749/image_1920?unique=b611535
Size : 50 µg Clone Number: Aliases: Advanced glycosylation end product-specific receptor antibody; Ager antibody; DAMA 358M23.4 antibody; MGC2235 antibody; MGC22357 antibody; RAGE_HUMAN antibody; Receptor for advanced glycation end products antibody; Receptor for advanced glycosylation end products antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q15109 Immunogen: Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: AGER Research Areas: Neuroscience; Cardiovascular

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Internal Reference: CSB-PA14209D0Rb