ALKBH1 Antibody

Size : 50 µL Clone Number: Aliases: ABH antibody; ABH1 antibody; alkB antibody; alkB homolog 1 histone H2A dioxygenase antibody; AlkB; alkylation repair homolog 1 (E. coli) antibody; ALKB1_HUMAN antibody; ALKBH antibody; ALKBH1 antibody; Alkylated DNA repair protein alkB homolog 1 antibody; Alkylation repair homolog 1 antibody; Alkylation repair; alkB homolog antibody; Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody; DNA lyase ABH1 antibody; DNA oxidative demethylase ALKBH1 antibody; hABH antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q13686 Immunogen: Fusion protein of Human ALKBH1 Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB; ELISA: 1: 1000-1: 2000, WB: 1: 200-1: 1000 Background: This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ALKBH1 Research Areas: Epigenetics and Nuclear Signaling