AIM2 Antibody, HRP conjugated
Size : 50 µg
Clone Number:
Aliases: Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_HUMAN antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody
Product Type: Polyclonal Antibody
Immunogen Species: Homo sapiens (Human)
UniProt ID: O14862
Immunogen: Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA)
Host: Rabbit
Reactivity: Human
Tested Applications: ELISA
Background: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Clonality: Polyclonal
Isotype: IgG
Purification Method: 95%, Protein G purified
Conjugate: HRP
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: Liquid
Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names: AIM2
Research Areas: Epigenetics and Nuclear Signaling; Cancer
Internal Reference:
CSB-PA001499LB01HU