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ABCB4 Antibody, FITC conjugated

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Size : 50 µg Clone Number: Aliases: ABC 21 antibody; ABC B4 antibody; ABC21 antibody; ABCB 4 antibody; Abcb4 antibody; ABCB4 protein antibody; ATP binding cassette sub family B MDR/TAP member 4 antibody; ATP binding cassette sub family B member 4 antibody; ATP-binding cassette sub-family B member 4 antibody; GBD1 antibody; ICP3 antibody; MDR 3 antibody; MDR2 antibody; MDR2/3 antibody; MDR3 antibody; MDR3 P glycoprotein antibody; MDR3 P gp antibody; MDR3_HUMAN antibody; Multidrug resistance protein 3 antibody; Multiple drug resistance 3 antibody; P glycoprotein 3 antibody; P-glycoprotein 3 antibody; PFIC 3 antibody; PFIC3 antibody; PGY 3 antibody; PGY3 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P21439 Immunogen: Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA) Host: Rabbit Reactivity: Human Tested Applications: Background: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed: 7957936, PubMed: 8898203, PubMed: 9366571, PubMed: 17523162, PubMed: 23468132, PubMed: 24806754, PubMed: 24723470, PubMed: 24594635, PubMed: 21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed: 23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed: 24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed: 9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed: 21820390). Does not confer multidrug resistance (By similarity). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: FITC Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ABCB4 Research Areas: Cancer; Metabolism; Signal transduction

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Internal Reference: CSB-PA001050LC01HU