CD163 Monoclonal Antibody

Size : 50 µL Clone Number: Aliases: Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)], CD163, M130 Product Type: Monoclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q86VB7 Immunogen: Synthesized peptide derived from human CD163 Host: Mouse Reactivity: Human Tested Applications: ELISA, IHC; Recommended dilution: IHC: 1: 20-1: 200 Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. Clonality: Monoclonal Isotype: IgG1, Kappa Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. Conjugate: Non-conjugated Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD163 Research Areas: Immunology