CD31 Monoclonal Antibody

Size : 50 µL Clone Number: 9E6E12 Aliases: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1 Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: P16284 Immunogen: Recombinant Human CD31 protein (28-315AA) Host: Mouse Reactivity: Human Tested Applications: ELISA, WB, IHC, IF, FC; Recommended dilution: WB: 1: 500-1: 5000, IHC: 1: 50-1: 500, IF: 1: 50-1: 200 Background: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed: 19342684, PubMed: 17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed: 19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed: 17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed: 12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed: 12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed: 18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed: 18672896). Induces susceptibility to atherosclerosis (By similarity). Clonality: Monoclonal Isotype: IgG2a Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD31 Research Areas: Cancer; Cardiovascular; Immunology; Signal transduction; Stem cells