CD146 Monoclonal Antibody

Size : 50 µL Clone Number: 4D10C7 Aliases: Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146), MCAM, MUC18 Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: P43121 Immunogen: Recombinant Human Cell surface glycoprotein MUC18 protein (50-646AA) Host: Mouse Reactivity: Human Tested Applications: ELISA, WB, IF, FC; Recommended dilution: WB: 1: 500-1: 2000, IF: 1: 50-1: 200 Background: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. Clonality: Monoclonal Isotype: IgG2a Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: CD146 Research Areas: Immunology